酪酸梭菌活菌散联合醒脾养儿颗粒对消化不良性腹泻患儿胃肠激素及免疫功能的影响

Effects of Clostridium Butyricum Viable Powder Combined with Xingpi Yanger Granule on Gastrointestinal Hormones and Immune Function in Children with Dyspepsia Diarrhea

目的探究消化不良性腹泻患儿采用酪酸梭菌活菌散联合醒脾养儿颗粒治疗对胃肠激素及免疫功能的影响.方法选取本院2019年3月—2021年3月收治的消化不良性腹泻患儿100例,按照随机数字表法分为对照组(50例)和观察组(50例).对照组冲服醒脾养儿颗粒,观察组加服酪酸梭菌活菌散,均持续治疗3个疗程.比较两组的胃肠激素、免疫功能及不良反应.结果治疗前,两组的各项胃肠激素及免疫功能指标比较,组间差异无统计学意义(P>0.05);治疗后,与对照组相比,观察组的生长抑素水平较高,胃泌素及胃动素水平均较低,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较高,CD8^(+)水平较低,组间差异有统计学意义(P<0.05).两组治疗期间均无严重不良反应.结论消化不良性腹泻患儿采用酪酸梭菌活菌散联合醒脾养儿颗粒治疗的效果确切,能够有效调节胃肠激素,改善免疫功能,缓解临床症状,且安全性高.

Objective To investigate the effect of Clostridium butyricum viable powder combined with Xingpi Yanger Granule on gastrointestinal hormone and immune function in children with dyspepsia diarrhea.Methods 100 children with dyspepsia diarrhea treated in our hospital from March 2019 to March 2021 were randomly divided into a control group(50 cases)and an observation group(50 cases).The control group was treated with Xingpi Yanger Granule and the observation group was treated with Clostridium butyricum viable powder on this basis.Both groups were treated for 3 courses.The gastrointestinal hormones,immune function and adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in gastrointestinal hormones and immune function indexes between the two groups(P>0.05);after treatment,compared with the control group,the level of somatostatin in the observation group was higher,the levels of gastrin and motilin were lower,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were higher,and the level of CD8^(+)was lower,the differences between the groups were statistically significant(P<0.05).There were no serious adverse reactions in both groups during treatment.Conclusion Clostridium butyricum viable powder combined with Xingpi Yanger Granule is effective in the treatment of children with dyspeptic diarrhea,which can effectively regulate gastrointestinal hormones,improve immune function and relieve clinical symptoms with high safety.