氨溴索联合多索茶碱治疗对慢性支气管炎患者血清炎性因子及肺功能的影响

The Effect of Ambroxol Combined with Doxofylline on Serum Inflammatory Factors and Lung Function in Patients with Chronic Bronchitis

目的 探讨氨溴索联合多索茶碱治疗对慢性支气管炎患者血清炎性因子及肺功能的影响.方法 选择该院2019年4月—2021年2月收治的慢性支气管炎患者90例为研究对象,根据随机数字表法分为两组,每组45例.对照组采用多索茶碱治疗,观察组采用氨溴索联合多索茶碱治疗,比较两组患者治疗前后的血清炎性因子水平、肺功能、血气分析指标,并观察其症状消失时间.结果 治疗后,观察组的各项血清炎性因子指标均低于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的各项肺功能指标均高于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的各项血气分析指标均优于对照组,组间差异有统计学意义(P<0.05).观察组的喘息、咳嗽咳痰、呼吸困难消失时间均明显短于对照组,组间差异有统计学意义(P<0.05).结论 氨溴索联合多索茶碱治疗对慢性支气管炎患者具有积极影响,不仅能够改善血清炎性因子指标水平,提升肺功能,还能缩短喘息、咳嗽咳痰及呼吸困难等症状的消失时间,值得推广使用.

Objective To investigate the effect of ambroxol combined with doxofylline treatment on serum inflammatory factors and lung function in patients with chronic bronchitis.Methods 90 patients with chronic bronchitis admitted to the hospital from April 2019 to February 2021 were selected as the research objects,and they were divided into two groups according to the random number table method,with 45 cases in each group.The control group was treated with doxofylline,and the observation group was treated with ambroxol combined with doxofylline.The levels of serum inflammatory factors,lung function,and blood gas analysis indexes of the two groups were compared before and after treatment,and the time of symptom disappearance was observed.Results After treatment,the serum inflammatory factors indexes of the observation group were lower than those of the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the pulmonary function indexes of the observation group were higher than those of the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the blood gas analysis indexes of the observation group were better than those of the control group,and the differences between the groups were statistically significant(P<0.05).The disappearance time of wheezing,coughing and sputum,and dyspnea in the observation group were significantly shorter than those in the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion Ambroxol combined with doxofylline therapy has a positive effect on patients with chronic bronchitis.It can not only improve the level of serum inflammatory factors,improve lung function,but also shorten the disappearance time of symptoms such as wheezing,coughing and sputum,and dyspena.It is worth promoting and usding.