活血化瘀药对肾病综合征患者血脂水平及肾功能的影响

Effects of Blood-Activating and Stasis-Removing Drugs on Blood Lipid Levels and Renal Function in Patients with Nephrotic Syndrome

目的探讨活血化瘀药对肾病综合征(NS)患者血脂水平及肾功能的影响.方法选取本院2018年9月—2020年10月收治的92例NS患者为研究对象,按照随机数字表法分为对照组与观察组,各46例.对照组接受常规治疗,观察组在对照组基础上加用活血化瘀药治疗,均连续治疗12周.对比两组临床疗效、血脂指标水平、肾功能指标水平、血浆白蛋白(ALB)水平以及不良反应发生情况.结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05).治疗前,两组三酰甘油(TG)、总胆固醇(TC)、24 h尿蛋白定量(24 h UPQ)、血清尿素氮(BUN)、ALB对比,差异无统计学意义(P>0.05);治疗后,观察组TG、TC、24 h UPQ、BUN均低于对照组,ALB高于对照组,差异有统计学意义(P<0.05).两组不良反应发生率相比,差异无统计学意义(P>0.05).结论临床将活血化瘀药应用于NS患者中可获得确切疗效,能够有效纠正血脂紊乱,改善肾功能,上调ALB水平,且不会增加不良反应,安全可行.

Objective To investigate the effect of blood-activating and stasis-removing drugs on blood lipid levels and renal function in patients with nephrotic syndrome(NS).Methods A total of 92 patients with NS who were admitted to our hospital from September 2018 to October 2020 were selected as the research objects,and divided into a control group and an observation group according to the random number table method,with 46 cases in each group.The control group received conventional treatment,and the observation group received blood-activating and stasis-removing drugs on the basis of the control group,and the treatment was continued for 12 weeks.The clinical efficacy,blood lipid indexes levels,renal function indexes levels,plasma albumin(ALB)levels and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in triglycerides(TG),total cholesterol(TC),24-hour urine protein quantification(24 h UPQ),blood urea nitrogen(BUN),and ALB(P>0.05);after treatment,TG,TC,24 h UPQ and BUN in the observation group were lower than those in the control group,and ALB was higher than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Clinical application of blood-activating and stasis-removing drugs in NS patients can obtain definite curative effect,which can effectively correct blood lipid disorders,improve renal function,and up-regulate ALB levels without increasing adverse reactions,which is safe and feasible.