加减补阳还五汤治疗气虚血瘀型2型糖尿病肾病Ⅲ期的临床疗效研究

Study on Clinical Efficacy of Modified Buyang Huanwu Decoction in Treating Type 2 Diabetic Nephropathy stage Ⅲ of Qi Deficiency and Blood Stasis Type

目的观察加减补阳还五汤治疗气虚血瘀型2型糖尿病肾病Ⅲ期的临床疗效.方法选择2020年1—12月该院收治的74例气虚血瘀型2型糖尿病肾病Ⅲ期患者为研究对象,按照随机数字表法分为治疗组和对照组,各37例.对照组口服缬沙坦治疗,治疗组口服加减补阳还五汤治疗.比较两组的治疗效果,测定两组治疗前后的生化指标、血清肾纤维化指标及氧化应激反应指标.结果治疗组的临床总有效率为89.19%,显著高于对照组的45.95%,差异有统计学意义(P<0.05).治疗后,治疗组患者的超敏C-反应蛋白、C3水平均优于对照组,组间差异有统计学意义(P<0.05).治疗后,治疗组的各项血清肾纤维化指标均优于对照组,组间差异有统计学意义(P<0.05).治疗后,治疗组的各项氧化应激反应指标均优于对照组,组间差异有统计学意义(P<0.05).结论加减补阳还五汤能降低气虚血瘀型2型糖尿病肾病Ⅲ期患者的尿微量白蛋白、超敏C-反应蛋白及C3水平,改善血清肾纤维化指标及氧化应激反应指标,疗效显著,值得进一步推广使用.

Objective To observe the clinical efficacy of modified Buyang Huanwu Decoction in treating Qi deficiency and blood stasis type 2 diabetic nephropathy stageⅢ.Methods 74 patients with Qi deficiency and blood stasis type 2 diabetic nephropathy stageⅢadmitted to the hospital from January to December 2020 were selected for the study.They were divided into a treatment group and an control group according to the random number table method,with 37 cases in each group.The control group was treated orally with valsartan,the treatment group was treated orally with modified Buyang Huanwu Decoction.The treatment effects of the two groups were compared,and the biochemical indexes,serum renal fibrosis indexes and oxidative stress indexes were measured before and after the treatment in the two groups.Results The total clinical efficiency of the treated group was 89.19%,which was significantly higher than 45.95%of the control group,and the difference was statistically significant(P<0.05).After treatment,the level of hypersensitive C-reactive protein and C3 in the treatment group were better than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,all the serum renal fibrosis indexes in the treatment group were better than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,all the oxidative stress indexes in the treatment group were better than those in the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion Modified Buyang Huanwu Decoction can reduce the levels of urinary microalbumin,ultrasensitive C-reactive protein and C3 in patients with type2 diabetic nephropathy stageⅢof Qi deficiency and blood stasistype,improve serum renal fibrosis indexes and oxidative stress indexes.It is effective and worthy of further promotion.