四妙散加减联合西药治疗湿热型强直性脊柱炎的临床疗效

The Clinical Effect of Modified Simiao Powder Combined with Western Medicine in Treatment of Damp-Heat Ankylosing Spondylitis

目的观察四妙散加减联合西药治疗湿热型强直性脊柱炎(ankylosing spondylitis,AS)的临床疗效.方法选取2018年2月—2019年9月中山市中医院脊柱科门诊部收治的60例湿热型AS患者为研究对象,将其随机分为两组,每组30例.对照组采用单纯西药治疗,观察组在对照组基础上联合四妙散加减治疗.比较两组患者的中医症状评分、炎症指标及疼痛视觉模拟评分(visual analogue scale,VAS).结果治疗后,观察组的关节冷痛、关节僵紧、关节僵痛、口不渴、便溏评分均低于治疗前,且关节冷痛、口不渴、便溏评分均低于对照组,组间差异有统计学意义(P<0.05).治疗后,两组的血沉(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein,CRP)水平均低于各组治疗前,且观察组的ESR、CRP水平均低于对照组,组间差异有统计学意义(P<0.05).在VAS评分方面,两组治疗后的评分均低于各组治疗前,且观察组评分低于对照组,组间差异有统计学意义(P<0.05).结论四妙散加减联合西药治疗湿热型AS的效果显著,值得在临床上广泛使用.

Objective To observe the clinical effect of Simiao Powder plus or minus combined with western medicine in the treatment of damp-heat type ankylosing spondylitis(AS).Methods From February 2018 to September 2019,60 patients with damp-heat ankylosing spondylitis admitted to the outpatient department of the Spine Department of Zhongshan Hospital of Traditional Chinese Medicine were selected as the research subjects,and they were randomly divided into two groups,with 30 cases in each group.The control group was treated with Western medicine alone,and the observation group was treated with Simiao Powder on the basis of the control group.The TCM symptom scores,inflammation index and pain visual analogue scale(VAS)score were compared between the two groups of patients.Results After treatment,the scores of joint cold pain,joint stiffness and tension and pain,joint stiffness,non-thirst,loose stools in the observation group were lower than before treatment,and the scores of joint cold pain,lack of thirst,and loose stools were lower than those of the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)levels of the two groups were lower than those of each group before treatment,and the ESR and CRP levels of the observation group were lower than those of the control group,the differences between the groups were statistically significant(P<0.05).In terms of VAS scores,the scores of the two groups after treatment were lower than those of each group before treatment,and the scores of the observation group were lower than those of the control group,the difference between the groups was statistically significant(P<0.05).Conclusion Modified Simiao Powder combined with western medicine is effective in treating damp-heat ankylosing spondylitis,which is worthy of being widely used clinically.