神经节苷脂联合神经康复治疗小儿脑瘫的临床效果观察

Observation of Clinical Effect of Ganglioside Combined with Nerve Rehabilitation on Children with Cerebral Palsy

目的以小儿脑瘫患儿作为研究对象,分析评价神经节苷脂联合神经康复治疗在其中的临床效果.方法该次将山东省临沂市罗庄办事处卫生院2018年2月—2019年1月收治的84例小儿脑瘫患儿作为研究对象,按随机数字表法分成两组,其中对照组42例采取神经节苷脂治疗,观察组42例则采取神经节苷脂联合神经康复治疗,比较两组临床治疗效果.结果(1)在两组康复总有效率方面,观察组为95.24%,与对照组的73.81%比明显更高,两组数据差异有统计学意义(P<0.05).(2)在智力状况(MDI)、运动功能(PDI)、生活活动能力(ADL)评分方面,治疗前两组比较差异无统计学意义(P>0.05);治疗后,观察组MDI、PDI、ADL评分均明显高于对照组,两组数据差异有统计学意义(P<0.05).(3)观察组、对照组用药不良反应总发生率均偏低,对比差异无统计学意义(P>0.05).结论小儿脑瘫患儿采取神经节苷脂联合神经康复治疗的疗效显著,可改善患儿的智力状况、运动功能及生活活动能力,且用药不良反应发生率低,安全高效,具备推广及使用的价值.

Objective To analyze and evaluate the clinical effect of ganglioside combined with neurorehabilitation in children with cerebral palsy.Methods 84 children with cerebral palsy admitted to Shandong Linyi Luozhuang Health Center from February 2018 to January 2019 were divided into two groups according to the random number table method,42 children in the control group were treated with ganglioside,42 children in the observation group were treated with ganglioside combined with neurorehabilitation,and the clinical treatment effect of the two groups was further compared.Results 1.In terms of the rehabilitation effect of the two groups,the total rehabilitation efficiency of the observation group was 95.24%,significantly higher than 73.81%of the control group,the difference was statistically significant(P<0.05).2.The differences in MDI,PDI and ADL scores between the two groups before treatment were not statistically significant(P>0.05);after treatment,the scores of MDI,PDI and ADL in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).3.The total incidence of adverse drug reactions in the two groups were both low,and the difference was not statistically significant(P>0.05).Conclusion The curative effect of ganglioside combined with neurorehabilitation is significant in children with cerebral palsy,which can improve the intelligence,motor function and life activity of the children,and the incidence of adverse drug reactions is low,safe and efficient.Therefore,it has the value of promotion and use.