摘要
Introduction Bullous pemphigoid(BP)is the most common subepidermal bullous disease and involves an immune response directed against two hemidesmosome components in basal keratinocytes:BP antigen 180(BP180)and BP antigen 230.The major epitope in patients with BP is the noncollagenous 16A(NC16A)domain of BP180.1 BP most commonly occurs in people of advanced age,especially those aged>70 years.The worldwide incidence of BP ranges from 12 to 66 cases per million people per year,and the disease prevalence increases with age.2 Degenerative neurological diseases,psychiatric disorders,and the chronic use of neuroleptics or spironolactone are known independent risk factors for the development of BP.3.
基金
the National Key Research and Development Program of China Grant(2016YFC0901500)
the National Natural Science Foundation of China(81972945)
the Milstein Medical Asian American Partnership Foundation and Education Reform Projects of Peking Union Medical College(2016zlgc0106)
