Meta-analysis of meditative/relaxation-based interventions for cognitive impairment in cancer patient

冥想或放松疗法对癌症患者认知受损干预效果的meta分析

Objective:This meta-analysis aimed to review any form of meditative/relaxation interventions for managing cognitive impairment in cancer patients,and to examine its intervention effect.Methods:Three databases(PubMed,PsycInfo,and CNKI)were searched until September 30,2016.Randomized controlled trials(RCTs)of meditative/relaxation-based interventions for the management of cognitive impairment in cancer patients were considered for inclusion.Results:A total of 4 RCTs were included in this meta-analysis.Four RCTs with a total of 290 subjects indicated that meditative/relaxation interventions significantly improved subjective cognitive function of cancer patients.The weighted mean difference was 5.29(95%CI:2.97,7.61).The overall effect of Z score was 4.47(P<0.001).The meditative/relaxation-based interventions had positive effects on the physical and mental QOL(quality of life)of cancer patients.Although the improvement of physical QOL was in favor of interventions,there is no statistically significant difference(Z score=1.81,P=0.07).For the effects of meditative/relaxation interventions on metal QOL,there is significantly statistical difference(Z score=2.99,P=0.003).All included RCTs had a follow-up assessment within six months.Conclusion:Mediation-based interventions had statistically significant difference in improve subjective cognitive function and mental QOL in cancer patients.However,since the conclusion of this meta-analysis was drawn based on limited number of RCTs,future research should be conducted to confirm its positive intervention effects.

目的评价任何形式的冥想或放松干预对癌症患者认知损伤的治疗效果。方法在3个数据库(PubMed.,PsycInfo和中国知网)进行文献检索,发表时间截至2016年9月30日。纳人的研究只包括对认知功能受损的癌症患者采用冥想/放松干预的临床随机对照试验(RCT)。结果共纳入4项RCT。这4项RCT总共包括290例受试者,随访时间均在干预后的6个月内。这些研究发现,冥想或放松干预疗法可显著改善癌症患者的主观认知功能,加权平均差为5.29(95%CI:2.97~7.61),Z评分的总体效应值为4.47(P<0.001)。冥想或放松干.预疗法对癌症患者的身体和精神方面的生活质量有积极的影响。对于身体方面的生活虽然有改善,但差异没有统计学意义(Z=1.81,P=0.07);精神方面的改善有统计学意义(Z=2.99,P=0.003)。结论冥想或放松干预疗法对癌症患者的主观认识功能和精神方面的生活质量有治疗效果,而且疗效具有统计学意义。由于该meta分析的结论是基于数量有限的RCT,所以需要相关研究进--步确认其积极的干预效果。