摘要
慢性心力衰竭是当前心血管疾病患者死亡的主要原因.β受体阻滞剂作为目前常应用于射血分数减低型心力衰竭的有效治疗药物,在射血分数非减低型心力衰竭中的作用尚有争议.近年来研究表明,对于射血分数保留型心力衰竭,β受体阻滞剂的预后作用可能与患者心率、β受体阻滞剂使用剂量、使用时间等因素相关.而在射血分数中间值心力衰竭中,则需要更多地考虑其病因,缺血性病因的患者可能更易获益于β受体阻滞剂.本文将针对β受体阻滞剂与射血分数非减低型心力衰竭的相关研究进展作一综述.
Chronic heart failure has become the main cause of mortality in patients with cardiovascular disease.However,the effect of beta-blockers on heart failure with non-reduced ejection fraction is still controversial though widely used in heart failure with reduced ejection fraction.Recent studies have shown that the effect of beta-blockers may correlates to factors like heart rate,dosage or duration of beta-blockers and etc.in patients with heart failure with preserved ejection fraction.For patients with heart failure with mid-range ejection fraction,those with ischemic etiology may be more likely to benefit from beta-blockers.This review is on the research progress of the association between beta-blockers and heart failure with non-reduced ejection fraction.
作者
林开阳
陈汉川
何晨
陈希男
王孙蓥
严晗
何浩铭
徐家豪
郭延松
Lin Kaiyang;Chen Hanchuan;He Chen;Chen Xinan;Wang Sunying;Yan Han;He Haoming;Xu Jiahao;Guo Yansong(Provincial Clinical Medical College,Fujian Medical University,Department of Cardiology,Fujian Provincial Hospital,Fuzhou 350001,China)
基金
国家自然科学基金(81873495)
福建省卫生和计划生育委员会青年科研课题(2015-1-9).
