心脏移植与肿瘤的研究进展

Research progress in heart transplantation and tumor

心脏移植是终末期心脏病的最后治疗手段.随着心脏移植生存率的提高,恶性肿瘤成为影响患者预后的主要原因之一.移植受者的总体肿瘤发病率比一般人群高3~5倍,免疫抑制治疗增加了受者发生恶性肿瘤的远期风险.心脏移植受者发生的恶性肿瘤来源分3类:移植术后新生肿瘤、移植供者传播的肿瘤和移植前恶性肿瘤的转移或复发.本文旨在总结目前心脏移植相关肿瘤的研究进展.

Heart transplantation is the last treatment choice for end-stage heart disease.With the increase in survival rate of heart transplantation,malignant tumor has become one of the main reasons affecting the prognosis of patients receiving heart transplantation.The overall incidence of tumor in recipients was 3 to 5 times higher than that in the general population,and immunosuppressive therapy increases the long-term risk of malignant tumors in recipients.The origin of malignant tumors in heart transplantation recipients can be divided into three categories:de novo malignancy(DNM)after heart transplantation,malignancy transmitted by donors with cancer history(DWCH),and the metastasis or recurrence of pre-transplant malignancy(PTM).The purpose of this article is to summarize the research progress in heart transplantation related tumors.