从脾胃气虚论治慢性萎缩性胃炎临床研究

目的 从脾胃气虚论治慢性萎缩性胃炎.方法 CAG患者106例,随机分为观察组与对照组,各53例,对照组根据辨证分型给予患者中药方剂加减治疗,观察组在对照组用药基础上加入黄芪、白术、党参各10g进行治疗;两组治疗30d为1个疗程,共治疗3个疗程.结果 观察组中医临床疗效的总有效率与痊愈率(94.34%、60.38%)与对照组(71.70%、32.08%)比较,差异有统计学意义(P<0.05);两组治疗后各临床症状与体征的痊愈情况比较,差异均有统计学意义(P<0.05,P<0.01);两组各时间段G-17、PGⅠ、PGR比较,差异均有统计学意义(P<0.05),其干预因素与时间因素亦存在交互作用(P<0.05).结论 采用增加健脾益气类药物的传统中药方剂治疗CAG疗效显著.

Objective To study the treatment of chronic atrophic gastritis from deficiency of spleen and stomach. Methods According to the corresponding criteria,106 cases of CAG patients were randomly divided into treatment group and basic group according to the order of 53 cases. The basic group was given the corresponding Chinese herbal formula according to syndrome differentiation to perform addition and subtraction treatment. The treatment group were added 10 grams each of Astragalus,Atractylodes and Codonopsis on the basic of control group. Both groups were treated with 30 days as a course of treatment with a total of 3 courses of treatment. Results The total effective rate and cure rate of clinical efficacy of traditional Chinese medicine treatment group were 94.34% and 60.38%,respectively,compared with 71.70% and 32.08% of the basic group,the differences were statistically significant(P<0.05). Comparison of the recovery of various clinical symptoms and signs after treatment in the two groups,the differences were statistically significant(P<0.05,P<0.01). Comparison of G-17,PGI andPGR in two groups at each time period,the differences were statistically significant(P<0.05),and there was also an interaction between intervention factors and time factors(P<0.05). Conclusion Treatment of CAG withtraditional Chinese herbal formulas with increased spleen-invigorating and Qi-inhibiting drugs has outstanding clinical efficacy.