益生菌联合精神 心理治疗肠易激综合征的疗效研究

目的 探讨益生菌联合精神、心理治疗肠易激综合征(IBS)患者的效果.方法 将2015年7月至2016年8月收治的110例IBS患者随机分为实验组(n=60)和对照组(n=50).对照组口服枯草杆菌二联活菌肠溶胶囊,2粒/次,3次/d,连用1个月.实验组在此基础上,联合认知行为干预,连续干预3个月.治疗前后对腹痛、腹泻、便秘等症状进行评分,采用焦虑自评量表(SAS)和抑郁自评量表(SDS)进行焦虑、抑郁评分,采用IBS生活质量量表(IBS-QOL)进行生活质量评分.观察临床治疗效果和不良反应.结果 治疗前,两组腹痛、腹泻、便秘症状评分,SAS、SDS、IBS-QOL评分差异无统计学意义(P>0.05).治疗后,两组腹痛、腹泻、便秘症状评分下降(P<0.05),SAS、SDS评分下降(P<0.05),IBS-QOL评分增加(P<0.05),实验组各指标改善程度明显优于对照组(P<0.05).实验组治疗效果优于对照组(P<0.05),两组不良反应发生率差异无统计学意义(3.3%?vs.?6.0%,P>0.05).结论 益生菌联合精神、心理治疗IBS安全、有效,值得临床推广应用.

Objective To investigate the effect of probiotics and psychotherapy in the treatment of irritable bowel syndrome(IBS).Methods 110 patients with IBS treated in our hospital from July 2015 to August 2016 were randomly divided into experimental group(n=60)and control group(n=50).The control group was treated with Live Combined Bacillus Subtilis and Enterococcus Faecium Enteric-coated Capsules,3 times/d,2 tablets/time,for a period of 1 months.The experimental group was treated with the combination of cognitive behavior intervention on the basis of the control group,continuous intervention for 3 months.Before and after treatment,the scores of abdominal pain,diarrhea and constipation symptoms were evaluated.The self-rating Anxiety Scale(SAS)and the self-rating Depression Scale(SDS)were used to evaluate the anxiety and depression scores.Quality of life was assessed by the use of the life rating scale for irritable bowel syndrome(IBS-QOL).The clinical therapeutic effects and adverse reactions were observed.Results Before treatment,the scores of abdominal pain,diarrhea and constipation symptoms,the scores of SAS,SDS and IBS-QOL of two groups had no statistically significant(P>0.05).After treatment,the scores of abdominal pain,diarrhea and constipation symptom decreased(P<0.05),the scores of SAS and SDS decreased(P<0.05),and IBS-QOL increased(P<0.05).The improvement degree of each index in the experimental group was significantly better than that of the control group(P<0.05).The clinical effect of the experimental group was better than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(3.3%vs.6.0%,P<0.05).Conclusion It is safe and effective in the treatment of irritable bowel syndrome with the combination of probiotics and psychotherapy.