肠道微生态参与炎症性肠病发病的研究进展

Role of intestinal microbiota in the pathogenesis of inflammatory bowel disease

炎症性肠病(IBD)是发生在胃肠道病因不明的慢性非特异性炎症性疾病,其发病与肠道菌群改变、肠道感染、肠屏障功能受损、异常免疫应答和基因易感等相关.随着研究不断进步,人们逐渐发现肠道微生态在IBD发病及治疗中起着至关重要的作用.本文就肠道微生物在IBD发病时的变化及对肠黏膜免疫应答调节和肠道微生态转化研究进行总结和阐述.

Inflammatory bowel disease(IBD)is a group of chronic non-specific inflammatory disorders which affects the gastrointestinal tract.The etiology and pathology are still unclear which may be associated with the change of intestinal microbiota,intestinal infections,compromised intestinal mucosal barrier integrity,dysregulated immune responses in gut mucosa and genetic susceptibility.With great progress of IBD studies in recent years,intestinal microbiota has been found to play a crucial role in the pathogenesis of IBD.In this article,we summarize the latest researches on intestinal microbiota which regulates mucosal immune responses and novel translational studies on microbiota alteration in the diagnosis and therapy in IBD.