益母草注射液联合缩宫素对产后出血量控制及第三产程的影响

Effect of Motherwort Injection Combined with Oxytocin on Postpartum Hemorrhage Volume Control and the Third Stage of Labor

目的:探讨益母草注射液与缩宫素联合治疗产后出血的价值。方法:根据随机数字表法将我院2016年5月—2018年6月自然分娩产后出血的100例产妇分为对照组与研究组,各50例,对照组单用缩宫素(胎儿娩出后产妇立即臀部肌肉注射10 IU,同时给予500 mL葡萄糖注射液静滴,每隔12 h注射1次缩宫素,共3次)治疗,研究组在使用缩宫素基础上联合应用益母草注射液(胎儿娩出后产妇即刻臀部肌肉注射20 mg益母草注射液,每隔12 h注射1次,连续注射3次),记录两组用药期间不良反应发生情况,比较两组分娩中、产后2 h、产后6 h、产后12 h、产后24 h出血量及第三产程时间,出院后电话随访询问产妇恶露持续时间,并告知于产后42 d来院复查子宫恢复情况。结果:产后6,12,24 h研究组出血量均少于对照组,差异有统计学意义(P <0.05);两组第三产程时间比较,差异无统计学意义(t=1.871,P=0.064);研究组恶露持续时间短于对照组,产后42 d宫底高度低于对照组,子宫体小于对照组,差异有统计学意义(P <0.05);两组治疗期间均无恶心、皮疹、发热等不良反应发生。结论:益母草注射液与缩宫素联合用于治疗产后出血的效果确切,可在一定程度上缩短产妇第三产程,缩短产后恶露持续时间,促进子宫复旧情况,安全可靠。

Objective:To investigate the value of motherwort injection combined with oxytocin in the treatment of postpartum hemorrhage.Methods:According to the random number table method,100 women with postpartum hemorrhage after spontaneous labor from May 2016 to June 2018 in our hospital were divided into a control group and a study group,50 cases each.The women in the control group were treated with oxytocin alone(gluteal intramuscular injection of 10 IU oxytocin was immediately given to the pregnant women after labor,500 mL glucose injection was given intravenously,and oxytocin was given once every 12 h for 3 times).The women in the study group were given motherwort injection(gluteal intramuscular injection of 20 mg motherwort injection was immediately given to the pregnant women after labor,once every 12 h,continuous injection for 3 times).The adverse reactions during drug use in the two groups were recorded.The hemorrhage volume during labor,2 h after labor,6 h after labor,24 h after labor and during the third stage of labor were compared,The duration of lochia was followed up by telephone after discharge,and the women were informed to reexamine uterine recovery 42 days after delivery.Results:The hemorrhage volume in the study group was less than that in the control group 6,12,24 h after labor,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the third stage of labor between the two groups(t=1.871 P=0.064).The duration of lochia in the study group was shorter than that in the control group,the height of fundus was lower than that in the control group 42 days after labor,and the bodies of uteruses in the study group were smaller than those in the control group,with statistically significant differences(P<0.05).There was no adverse reaction such as nausea,rash and fever during the treatment.Conclusion:Motherwort injection combined with oxytocin is effective in treating postpartum hemorrhage,and can shorten the third stage of labor,shorten the duration of postpartum lochia and promote the recovery of uteruses,which is safe and reliable.