降钙素原在环磷酰胺治疗系统性红斑狼疮感染与活动期的鉴别价值及临床意义

Identifying Value and Clinical Significance of Procalcitonin in the Treatment of Systemic lupus Erythematosus Infection and Active Phase with Cyclophosphamide

目的:探讨降钙素原(PCT)在环磷酰胺治疗系统性红斑狼疮(SLE)感染与活动期的鉴别价值及临床意义。方法:选取2016年2月—2017年2月我院收治的SLE感染患者40例与SLE活动期患者40例,分为SLE感染组及SLE活动期组,两组均应用环磷酰胺治疗,比较两组治疗前后PCT水平以及阳性表达情况。结果:SLE感染组PCT阳性表达情况显著高于SLE活动期组,差异有统计学意义(P <0.05);治疗后SLE感染组PCT水平高于SLE活动期组,差异有统计学意义(P <0.05)。结论:PCT水平能够早期鉴别SLE感染及活动期,为环磷酰胺的合理使用提供可靠依据,对于改善SLE患者预后具有重要价值。

Objective:To investigate the identifying value and clinical significance of procalcitonin(PCT)in the treatment of systemic lupus erythematosus(SLE)infection and active phase with cyclophosphamide.Methods:40 patients with SLE infection and 40 patients with active SLE admitted to our hospital from February 2016 to February 2017 were selected and divided into a SLE infection group and a SLE active phase group.The patients in the two groups were treated with cyclophosphamide.The level of PCT and positive expression before and after treatment were compared between the two groups.Results:The positive expression of PCT in the SLE infection group was significantly higher than that in the SLE active phase group,with statistically significant difference(P<0.05).The level of PCT in the SLE infection group was higher than that in the SLE active phase group after treatment,with statistically significant difference(P<0.05).Conclusion:The level of PCT can identify early SLE infection and active phase and provide a reliable basis for the rational use of cyclophosphamide,and is of great value for improving the prognosis of patients with SLE.