雷贝拉唑三联疗法治疗HP阳性消化性溃疡的疗效研究

Study on Therapeutic Effect of Rabeprazole Triple Therapy in the Treatment of HP-positive Peptic Ulcer

目的 :探讨雷贝拉唑三联疗法治疗幽门螺杆菌(HP)阳性消化性溃疡的疗效及安全性。方法 :选取我院收治的HP阳性消化性溃疡患者108例,依照随机数字表法分为观察组和对照组,各54例。对照组采取奥美拉唑三联疗法[奥美拉唑(20 mg,bid)+阿莫西林(1 g,bid)+克拉霉素(500 mg,bid)]治疗,观察组采取雷贝拉唑三联疗法[雷贝拉唑(20 mg,bid)+阿莫西林(1 g,bid)+克拉霉素(500 mg,bid)]治疗。比较两组治疗效果、HP根除率、不良反应发生率与治疗后6个月溃疡复发率。结果 :观察组治疗效果优于对照组,差异有统计学意义(P <0.05);治疗后观察组HP根除率为90.74%,高于对照组的75.93%,差异有统计学意义(P <0.05);两组不良反应总发生率比较,差异无统计学意义(P> 0.05);观察组溃疡复发率低于对照组,差异有统计学意义(P <0.05)。结论 :雷贝拉唑三联疗法治疗HP阳性消化性溃疡可显著提高治疗效果,提升HP根除率,降低溃疡复发风险,且安全性高。

Objective:To investigate the effcacy and safety of rabeprazole triple therapy in the treatment of Helicobacter pylori(HP)-positive peptic ulcer.Methods:108 patients with HP-positive peptic ulcer admitted to our hospital were enrolled and randomly divided into an observation group and a control group,54 cases in each group.The patients in the control group were given omeprazole triple therapy[omeprazole(20 mg,bid)+amoxicillin(1 g,bid)+clarithromycin(500 mg,bid)],and the patients in the observation group were given rabeprazole triple therapy[rabeprazole(20 mg,bid)+amoxicillin(1 g,bid)+clarithromycin(500 mg,bid)].The therapeutic effect,HP eradication rate,incidence of adverse reactions and ulcer recurrence rate after 6 months of treatment were compared between the two groups.Results:The therapeutic effect in the observation group was better than that in the control group,with statistically significant difference(P<0.05).The HP eradication rate in the observation group was 90.74%,which was higher than 75.93%in the control group,with statistically significant difference(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of ulcers in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).Conclusion:The rabeprazole triple therapy for HP-positive peptic ulcer can significantly improve the therapeutic effect,improve HP eradication rate and reduce the risk of ulcer recurrence,and has high safety.