壳聚糖宫颈膜联合多西环素治疗非淋菌性宫颈炎的疗效

Efficacy of Chitosan Cervical Membrane Combined with Doxycycline in the Treatment of Non-gonococcal Cervicitis

目的 :探讨壳聚糖宫颈膜联合多西环素治疗非淋菌性宫颈炎的疗效及对患者血清炎性因子水平的影响。方法 :选取2014年1月—2014年12月我院收治的非淋菌性宫颈炎患者50例,按照随机数字表法分为观察组和对照组,各25例,对照组使用多西环素(100 mg,bid)治疗,观察组在对照组基础上给予壳聚糖宫颈膜(1次/周)治疗,3个月为一疗程。比较两组临床疗效、治疗前后炎性因子水平、症状缓解时间及不良反应发生情况。结果:观察组总有效率为96.0%,高于对照组的84.0%,差异有统计学意义(P <0.05);治疗前两组超敏C反应蛋白(Hs-CRP)、白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α比较,差异无统计学意义(P> 0.05);治疗后,两组Hs-CRP、IL-6、TNF-α水平较治疗前显著降低,且观察组低于对照组,差异有统计学意义(P <0.05);观察组创面脱痂时间、阴道止血时间、阴道排液时间和创面愈合时间短于对照组,差异有统计学意义(P <0.05);观察组发生纳差、腹泻、恶心呕吐、发热例数少于对照组,差异有统计学意义(P <0.05)。结论 :壳聚糖宫颈膜联合多西环素治疗非淋菌性宫颈炎的疗效显著,可明显改善血清炎性因子水平,促进创面愈合,且安全性好,值得临床进一步推广。

Objective:To investigate the effcacy of chitosan cervical membrane combined with doxycycline in the treatment of non-gonococcal cervicitis and its effect on serum inflammatory factor levels.Methods:50 patients with non-gonococcal cervicitis admitted to our hospital from January 2014 to December 2014 were enrolled and randomly divided into an observation group and a control group,25 cases in each group.The patients in the control group were treated with doxycycline(100 mg,bid)treatment,and the patients in the observation group were given chitosan cervical membrane(1 time/week)on the basis of the control group,3 months for a course of treatment.The clinical effcacy,inflammatory factor levels,symptom relief time and adverse reactions were compared between the two groups.Results:The total effective rate in the observation group was 96.0%,which was higher than 84.0%in the control group,with statistically significant difference(P<0.05).There were no significant differences in the levels of high-sensitivity C-reactive protein(Hs-CRP),interleukin(IL)-6 and tumor necrosis factor(TNF)-αbefore treatment between the two groups.The levels of Hs-CRP,IL-6 and TNF-αin the two groups after treatment were significantly lower than those before treatment,and the levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The wound decrustation time,vaginal hemostasis time,vaginal discharge time and wound healing time in the observation group were shorter than those in the control group,with statistically significant differences(P<0.05).The incidences of anorexia,diarrhea,nausea and vomiting,and fever in the observation group were less than those in the control group,with statistically significant differences(P<0.05).Conclusion:The chitosan cervical membrane combined with doxycycline is effective in the treatment of nongonococcal cervicitis,and can significantly improve serum inflammatory factor levels and promote wound healing,which is safe and worthy of further clinical promotion.