头孢曲松治疗儿童大叶性肺炎的临床疗效研究

Study on Clinical Efficacy of Ceftriaxone in the Treatment of Lobar Pneumonia in Children

目的 :探讨头孢曲松治疗大叶性肺炎的临床疗效。方法 :选取2016年1月—2017年8月我院收治的82例大叶性肺炎患儿,按治疗方案的不同分为对照组(40例)和观察组(42例)。两组均给予常规对症治疗,在此基础上,对照组给予头孢噻肟钠(50～100 mg/kg,qd)治疗,观察组给予头孢曲松(40～80mg/kg,qd)治疗,比较两组临床疗效、咳嗽喘息及肺部啰音消失时间、体温恢复正常时间和住院时间,监测两组用药安全情况。结果 :观察组治疗总有效率为90.48%,显著高于对照组的77.50%,差异有统计学意义(P <0.05);观察组咳嗽喘息消失时间、肺部啰音消失时间、体温恢复正常时间及住院时间均显著短于对照组,差异有统计学意义(P <0.05);两组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论 :头孢曲松治疗儿童大叶性肺炎的临床疗效可靠,能快速改善患儿临床症状及体征,安全性高。

Objective:To investigate the clinical effcacy of ceftriaxone in the treatment of lobar pneumonia in children.Methods:82 children with lobar pneumonia admitted to our hospital from January 2016 to August 2017 were selected and divided into a control group(40 cases)and an observation group(42 cases)according to different treatment options.The patients in the two groups were given conventional symptomatic treatment.On this basis,the patients in the control group were treated with cefotaxime sodium(50~100 mg/kg,qd),and the patients in the observation group were treated with ceftriaxone(40~80 mg/kg,qd).The clinical effcacy,the disappearance time of cough and wheezing and lung rales,the time of normal temperature recovery and the time of hospitalization were compared between the two groups.The safety of drug use in the two groups was monitored.Results:The total effective rate in the observation group was 90.48%,which was significantly higher than 77.50%in the control group,and the difference was statistically significant(P<0.05).The disappearance time of cough and wheezing and lung rales,the time of normal temperature recovery and the time of hospitalization in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Ceftriaxone is reliable in the treatment of lobar pneumonia in children,and can quickly improve the clinical symptoms and signs of the children,and has high safety.