泮托拉唑和生长抑素联合治疗重症急性胰腺炎的效果和血清指标分析

Analysis on Efficacy of Pantoprazole Combined with Somatostatin in the Treatment of Severe Acute Pancreatitis and Its Effect on Serum Indexes

目的:分析泮托拉唑和生长抑素联合治疗重症急性胰腺炎(SAP)的效果及对患者血清指标的影响.方法:将2016年1月—2017年12月我院收治的92例SAP患者按随机数字表法分为观察组和对照组,各46例.对照组在常规治疗的基础上行泮托拉唑(40 mg加入100 mL的0.9% 氯化钠注射液中,ivgtt,qd)治疗,观察组在对照组基础上联合生长抑素[3 mg加入500 mL的0.9% 氯化钠注射液中,静脉泵入,bid]治疗.比较两组临床治疗效果;比较两组治疗前后血淀粉酶(Amy)、尿淀粉酶(UAmy)和血清指标[C反应蛋白(CRP)、白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α]水平.结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组平均Amy、UAmy较治疗前均下降,且观察组低于对照组,差异有统计学意义(P<0.05);两组平均血清CRP、IL-8、TNF-α 水平较治疗前均下降,且观察组均低于对照组,差异有统计学意义(P<0.05).结论:泮托拉唑联合生长抑素治疗SAP的疗效显著,能有效降低患者的血清指标,改善炎症反应状态,值得临床推广应用.

Objective:To analyze the efficacy of pantoprazole combined with somatostatin in the treatment of severe acute pancreatitis(SAP)and its effect on serum indexes.Methods:92 patients with SAP admitted to our hospital from January 2016 to December 2017 were randomly divided into an observation group and a control group,46 cases each.The patients in the control group were treated with pantoprazole(40 mg drug was added to 100 mL 0.9%sodium chloride injection,ivgtt,qd)on the basis of conventional treatment,and the patients in the observation group were further treated with somatostatin[3 mg drug was added to 500 mL 0.9%sodium chloride injection,intravenous pumping,bid].The clinical therapeutic effect was compared between the two groups.The levels of blood amylase(Amy),urinary amylase(UAmy)and serum indexexs[C-reactive protein(CRP),interleukin(IL)-8,tumor necrosis factor(TNF)-α]before and after treatment were compared between the two groups.Results:The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The average levels of Amy and UAmy after treatment were lower than those in the two groups,and the levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The mean serum levels of CRP,IL-8 and TNF-αafter treatment were lower than those before treatment in the two groups,and the levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion:Pantoprazole combined with somatostatin is significantly effective in the treatment of SAP,which can effectively reduce the levels of serum indexes in the patients and improve the inflammatory response state of the patients,which is worthy of clinical popularization and application.