中药对脑缺血后Nogo-A、NgR、Rho-A影响的研究概况

Effects of Chinese Herbology on Nogo-A, NgR and Rho-A after Cerebral Ischemia

导致中枢神经系统功能受损的重要原因是缺血引起的脑损伤.使损伤神经再生成为患者神经功能是否能恢复或改善的核心问题.中药通过多途径、多靶点对脑缺血后产生保护作用.轴突生长抑制因子 -A ( neurite out-growth inhibitor, Nogo-A) 、 Nogo-66受体 ( NgR) 、 Rho-A通过中药作用, 对于神经损伤后的恢复治疗有一定的独特优势.

In recent years,the incidence of cerebral apoplexy has increased significantly.It has the characteristics of high fatality rate,high disability rate and high recurrence rate.However,the major cause of impairment of the central nervous system is brain damage caused by ischemia.How to make the injured nerve regeneration become the core problem of whether the nerve function can be restored or improved.Traditional Chinese medicine has protective effects on cerebral ischemia through multiple pathways and multiple targets.Nogo-A,NgR,Rho-A through the role of traditional Chinese medicine,for the recovery of nerve injury after treatment has a unique advantage.