前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的疗效

The effect of alprostadil combined with benazepril treatment of diabetic nephropathy proteinuria

目的:糖尿病肾病患者采用前列地尔联合那普利治疗,分析其对尿蛋白的治疗效果。方法选取我院2011年6月—2013年6月收治的78例糖尿病肾病患者,随机分为观察组和对照组,两组患者均给予贝那普利片治疗,观察组在此基础上联合前列地尔注射液进行治疗,对两组患者的治疗效果进行对比观察。结果观察组治疗有效率为92.3%,对照组治疗有效率为79.4%,观察组高于对照组,两组数据对比具有统计学意义(P<0.05)。治疗2个月后,观察组24h尿蛋白含量与24h尿微白蛋白排血率明显低于对照组,两组数据对比具有统计学意义(P<0.05)。结论糖尿病肾病患者采用前列地尔联合那普利治疗与单纯采用贝那普利治疗相比,具有显著效果,可有效降低尿蛋白含量,控制尿微白蛋白排泄率,值得临床推广。

Objective To analyze the treatment effect of alprostadil combined with benazepril on urine protein in the patients with diabetic nephropathy.Methods A total of 78 cases of diabetic nephropathy patients who treated in our hospital between June 2011 to June 2013 were collected,and divided into observation group and control group.The patients in both two groups were treated with benazepril treatment,and the patients in the observation group received alprostadil injection based on it,then comparatively observed the treatment effect between two groups.Results The effective rate of the observation group(92.3%)was higher than that of the control gorup(79.4%),and there was significant difference between two groups(P<0.05).After treatment for 2 months,the urine protein content and urinary albumin excretion rate of the observation group at 24 hours were significantly lower than those of the control group,and there was significant difference between two groups(P<0.05).Conclusions The alprostadil combined with benazepril has significant effect in the treatment of diabetic nephropathy patients when compared with the single application of benazepril,it can effectively decrease the urine protein content and control urinary albumin excretion rate,which is worthy of clinical promotion.