7Martinez FJ, Donohue JF, Rennard SI. The future of chronic obstructive pulmonary disease treatment: difficulties of and barriers to drug develop- ment [J~ . Lancet, 2011, 378 (9795): 1027-1037.
8Sundar I K, Hwang JW, Wu S, et al. Deletion of vitamin Dreceptor leads to premature emphysema/COPD by increased matrix metalloproteinase'sand lymphoid aggregates formation (J ~ . Biochem Biophys Res Com- mun, 2011,406 (1): 127-133.
9Morjaria J, Malerba M, Polosa R. Biologic and pharmacologic therapies in clinical development for the inflammatory response in COPD [J~ .Drug Disc Today, 2010, 15 (5) : 396 -405.
10Murakami S, Nagaya N, Itoh T, et al. Adrenomedullin regenerates alve- oil and vasculature in elastase- induced pulmonary emphysema in mice [J3 . Am J Respir Crit Care Med, 2012, 172 (5) : 581 -589.