肿瘤标志物在肺癌辅助诊断中的应用

Application of Tumor Markers in the Diagnosis of Lung Cancer

目的:肺癌肿瘤标志物在肺癌诊断、复发、手术评估方面均有较高价值,本研究探讨5种血清肿瘤标志物神经原特异性烯醇化酶(NSE)、癌胚抗原(CEA)、癌抗原125(CA125)、细胞角蛋白19片段(CYFRA21-1)和鳞状细胞癌抗原(SCC)在肺癌辅助诊断中的应用价值,及敏感性和特异性最高的肿瘤标志物组合。方法收集120例肺癌患者,80例健康人和98例肺部良性疾病患者血清。以上5种标志物水平均采用酶联免疫吸附实验(ELISA)检测。结果肺癌患者的5种血清肿瘤标志物水平均明显高于非肿瘤组、健康组和良性疾病组,差异有统计学意义(<0.01)。其中NSE在小细胞肺癌、CYFRA21-1、鳞癌抗原(SCC)在鳞癌中的水平明显高于其他类型的肺癌;NSE对小细胞肺癌检测的敏感性明显高于其他类型的肺癌;以上5种血清癌标志物经组合后,敏感性明显高于任一单项癌标志物(<0.01)。结论5种血清肿瘤标志物对于肺癌的辅助诊断有一定的临床意义。

Objective Lung cancer tumor markers in lung cancer diagnosis and assessment of recurrence,surgery has a higher value,.This study of 5 kinds of serum tumor markers in diagnosis of lung cancer application,including the neuron-specific enolase(NSE)and carcinoembryonic Antigen(CEA)and cancer Antigen 125(CA125)and Cytokeratin 19 fragment()and squamous cell carcinoma Antigen(SCC);Methods 120 cases of patients with lung cancer,80 healthy and Sera of 98 patients with benign disease.Above 5 kinds of markers are made of Elisa experiments(ELISA)testing.Results 5 kinds of serum tumor markers in patients with lung cancer are significantly higher than the non-tumor group and healthy groups and benign disease group,a statistically significant difference(<0.01).NSE in small cell lung cancer,CYFRA21-1 and squamous cell carcinoma Antigen(SCC)Squamous cell carcinomas were significantly higher than those in other types of lung cancer(<0.01);Detection sensitivity of NSE for small cell lung cancer was significantly higher than other types of lung cancer(<0.01);More than 5 kinds of serum tumor markers combination,sensitivity was significantly higher than any single cancer markers(<0.01).Conclusion 5 kinds of serum tumor markers for lung cancer diagnosis has clinical significance.NSE can be used as a marker for detection of small cell lung cancer;CEA+CYFRA21-1+SCC can be used to inspect non-small cell lung cancer with combination of markers.CYFRA21-1+SCC can be used to inspect combinations of markers in lung squamous cell carcinoma.