早期大剂量纳洛酮在急性重型颅脑损伤中的应用观察

Clinical Study of Acute Severe Craniocerebral Injury Early Treatment of Large Dose of Naloxone

目的:探讨早期大剂量纳洛酮治疗重型颅脑损伤的临床疗效。方法将70例重型颅脑损伤患者随机分为两组,均给予常规治疗,在此基础上,观察组加用纳洛酮治疗。结果观察组生命体征较快恢复稳定,觉醒时间缩短,伤后3个月GOS评分。观察组显著高于对照组。结论大剂量纳洛酮可有效改善患者脑水肿与减轻中枢神经系统损害,不失为治疗脑损伤的有效药物。

Objective To investigate the clinical ef ect of early large dose of naloxone in treatment of severe craniocerebral injury.Methods 70 cases of severe traumatic brain injury were randomly divided into 2 groups,were given conventional treatment,on this basis,the observation group treatment with naloxone.Results In the observation group,vital signs rapidly restore stability,awakening time,3 months after injury,GOS score.The observation group was significantly higher than that of control group.Conclusion A large dose of naloxone can ef ectively improve the patients of brain edema and reduce the damage of central nervous system,ef ective drug to treat brain injury.