1,3-β-D葡聚糖检测对侵袭性真菌感染的临床诊断研究

1,3-beta Glucan Detection-D Study on Clinical Diagnosis of Invasive Fungal Infection

目的探讨1,3-β-D葡聚糖检测对侵袭性真菌感染的临床诊断。方法选择于2013年1月~12月确诊的30例侵袭性真菌感染患者、20例真菌口咽定植患者、20例细菌学肺炎患者以及15名健康人作为研究对象,对于以上对象的血浆1,3-β-D葡聚糖浓度通过G试验方法进行检测。结果 IFI患者的血浆1,3-β-D葡聚糖浓度为(29.5±11.5)ns/L,真菌口咽定植组为(12.7±5.1)ns/L,细菌性肺炎组为(13.1±5.2)ns/L,而健康组为(11.7±3.5)ns/L,通过比较可得均具有差异性。结论真菌口咽定植者、细菌性肺炎患者、健康者的血浆1,3-β-D葡聚糖浓度均低于IFI患者,诊断IFI的指标为血浆1,3-β-D葡聚糖浓度。

Objective To investigate the-D 1,3-beta glucan detection for clinical diagnosis of invasive fungal infections.Methods From 2013 January to December was diagnosed in 30 patients,20 cases of invasive fungal infection in patients with oropharyngeal colonization of fungi,20 cases of bacterial pneumonia patients and 15 healthy people as the research object,the object of the plasma levels of 1,3-β-D dextran concentration for detection by G test method.Results IFI plasma 1,3-β-D dextran concentration was(29.5±11.5)ns/L,fungal colonization group of oropharynx(12.7±5.1)ns/L,bacterial pneumonia group(13.1±5.2)ns/L,and healthy group(11.7±3.5)ns/L,by comparing the available have dif erence.Conclusion Health fungi oropharyngeal colonization,bacterial pneumonia patients,the plasma levels of 1,3-β-D dextran concentrations were lower in IFI patients,the diagnosis of IFI index for plasma 1,3-β-D dextran concentration.