2Hogg JC,Chu F,Utokaparch S,et al.The nature of small-airway obstruction in chronic obstructive pulmonary disease.N Engl J Med,2004,350:2645-2653.
3Demedts IK,Bracke KR,Van Pottelberge G,et al Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2007,175:998-1005.
4Costa C,Rufino R,Traves SL,et al.CXCR3 and CCR5 chemokines in induced sputum from patients with COPD.Chest,2008,133:26-33.
5Maeno T,Houghton AM,Quintero PA,et al.CD8 + T Cells are required for inflammation and destruction in cigarette smoke induced emphysema in mice.J Immunol,2007,178:8090-8096.
6Sullivan AK,Simonian PL,Falta MT,et al.Oligoclonal CD4 + T cells in the lungs of patients with severe emphysema.Am J Respir Crit Care Med,2005,172:590-596.
7Motz GT,Eppert BL,Sun G,et al.Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette.smoke-induced emphysema.J Immunol,2008,181:8036-8043.
8Hodge G,Nairn J,Holmes M,et al.Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood,bronchoalveolar lavage and intraepithelial T cells of COPD subjects.Clin Exp Immunol,2007,150:22-29.
9Barnes PJ.Immunology of asthma and chronic obstructive pulmonary disease.Nat Rev Immunol,2008,8:183-192.
10Viglietta V,Baecher-AllanC,WeinerHL,etaL Lossof functional suppression by CD4 + CD25 +regulatory T cells in patients with multiple sclerosis.J Exp Med,2004,199:971-979.
