滥用抗生素对老年社区获得性肺炎病原体分布的影响研究

Researches on Effect to Acquired Pneumonia of Seniors in Community by Abuse of Antibiotics

目的:研究滥用抗生素对老年社区获得性肺炎病原体分布的影响。方法随机选取200例有明确滥用抗生素病史的老年社区获得性肺炎患者作为滥用抗生素组,再随机选取200例正规使用抗生素的老年社区获得性肺炎患者作为正规治疗组,比较两组患者细菌培养结果的差异。结果滥用抗生素组与正规治疗组比较,革兰氏阴性杆菌、非典型病原体、肺炎支原体、真菌和白色念珠菌的感染显著增加,差异有统计学意义,<0.05。结论滥用抗生素使老年社区获得性肺炎的病原体分布发生了明显的变化,主要表现在革兰氏阴性杆菌、非典型病原体、肺炎支原体、真菌和白色念珠菌的感染显著增加。

Objective To research the effect to acquired pneumonia of seniors in community by abuse of antibiotics.Methods Randomly choosing 100 cases of acquired pneumonia of seniors in community who obviously abused antibiotics as antibiotics group,and randomly choosing 100 cases who used antibiotics as regular group,compare the dif erences between the results of bacterial culture in the two groups.Results Comparing two groups,Gram-Negative bacil us,Atypical pathogens,Eaton's agent and CA increased greatly,the dif erences had statistical significance,<0.05.Conclusion Changes of pathogen distribution were taken place by abusing antibiotics of seniors in community,mainly appeared as the infection by Gram-Negative bacil us,Atypical pathogens,Eaton's agent and CA increased greatly,which required clinicians should use antibiotics reasonably,and dynamic monitor the pathogens distribution and drug resistance.