莉芙敏治疗人工绝经术后绝经症状临床疗效观察

Remifemin Artificial Menopause Symptoms of Menopause after Clinical Curative Effect Observation

目的:观察莉芙敏改善妇科人工绝经患者术后的围绝经期综合征的疗效。方法80例育龄妇女,因手术切除双侧卵巢或因放射疗法使双侧卵巢功能受损,根据用药意愿分为莉芙敏研究组及对照组。随访12w。以Kupperman绝经期指数( KMI)总分为主要疗效评价指标,以KMI各单项指标作为次要疗效评价指标,以肝功能、激素水平、血脂水平等实验室检查项目作为安全性指标,对用药前后进行组间、组内比较。结果应用莉芙敏治疗12w后,患者的围绝经期综合征症状明显缓解;用药前后KMI评分差异显著,与对照组比较及治疗前后比较差异有统计学意义(P<0.001);治疗组用药前后血FSH、E2水平无明显变化,差异无统计学意义(P>0.05);治疗组用药前后肝功及血脂相关指标的差异无统计学意义(>0.05)。结论莉芙敏治疗人工绝经患者术后的围绝经期综合征有较好的临床疗效,能有效改善围绝经期综合征妇女的临床症状,安全性高且依从性好,患者易于接受,值得临床进一步应用。

Objective To observe the Remifemin improved artificial postmenopausal patients of department of gynaecology the curative ef ect of perimenopausal syndrome after the operation.Methods 80 cases of women of childbearing age,because of the surgical removal of the bilateral ovaries or make bilateral ovarian function damage with radiation therapy,according to the medicine wil divided into Remifemin group and the control group.Follow-up of 12 weeks.With Kupperman menopause index(KMI)total score as the main curative ef ect evaluation index,with every single index as a secondary effect of KMI evaluation index,such as liver and kidney function,hormone levels,laboratory examination project as a safety measure,to compare between groups,group before and after medication.Results Application of Remifemin after 12 weeks of treatment in patients with perimenopausal syndrome symptoms eased significantly;KMI scores before and after medication significant dif erence,compared with the control group and compare the difference was statistical y significant before and after the treatment(<0.001);Treatment group blood FSH,E2 level no obvious change before and after medication,there was no statistically significant dif erence(>0.05);Treatment group before and after medication liver result and differences of blood lipid related index has no statistical significance(>0.05).Conclusion Remifemin artificial postmenopausal patients with postoperative treatment of perimenopausal syndrome has bet er clinical curative ef ect,can ef ectively improve the clinical symptoms of perimenopausal syndrome women,high safety and good compliance,patients are easy to accept,is worth further clinical application.