新诊T2DM患者血浆RBP4与髂动脉内中膜厚度的关系研究

Relationship between Plasma Retinol-binding Protein 4 and Intima-media Thickness of Common Iliac Artery in Newly Diagnosed Type 2 Diabetics

目的:探讨新诊2型糖尿病(T2DM)患者血浆视黄醇结合蛋白4(RBP4)与髂动脉内中膜厚度(CIA-IMT)的关系。方法180例新诊T2DM患者测定血浆RBP4浓度、血糖、糖化血红蛋白(HbA1c)、血脂、胰岛素(FINS)及CIA-IMT,根据RBP4浓度由低到高按三分位法将180例患者分为三组,比较其CIA-IMT;用Pearson相关分析分析RBP4与其他指标的相关性。结果T2DM患者RBP4上三分位组CIA-IMT比其余两组增厚,差异有统计学意义(P<0.05);Pearson相关分析显示T2DM患者血浆RBP4与BMI、FBS、PBS、FINS及HOMA-IR呈正相关。结论新诊T2DM患者的血浆RBP4水平与CIA-IMT密切相关。

Objective To evaluate the relationship between the concentration of plasma retinol-binding protein 4(RBP4)and intima-media thickness of common iliac artery(CIA-IMT)in newly diagnosed type 2 diabetic(T2DM)patients.Methods There were 180 newly diagnosed T2DM patients in study.Their plasma retinol-binding protein 4 level and other clinic index were tested.The patients were divided into three groups based on the concentrations of RBP4 to compare their CIA-IMT.The relevance of RBP4 and other parameters were analyzed by Pearson correlation analysis.Results CIA-IMT of RBP4 high tertile group was significantly thicker than other groups(P<0.05).It is showed by Pearson correlation analysis that the concentration of RBP4 in T2DM patients is positively correlated with BMI,FBS,PBS,FINS and HOMA-IR.Conclusion CIA-IMT in newly diagnosed T2DM patients is closely correlated with plasma RBP4 levels.