山豆根生物碱化学成分及药理研究现状

The Chemical Structure and Pharmacological Actions of Alkaloids in Radix Sophorae Tonkinensis

目的:对山豆根的生物碱成分,保肝作用及其不良反应研究现状做一概述。方法查阅国内外相关文献,并进行综合、分析和归纳。结果山豆根含丰富的喹诺里西啶(quinolizidine)类生物碱,主要为苦参碱、氧化苦参碱。其保肝作用的主要成分为苦参碱和氧化苦参碱,引起不良反应的原因为其所含的金雀花碱等菸碱样毒性有关,也可能为用量有关。结论山豆根具有极大的药用价值,但同时对其质量控制尤为重要。

The chemical structure of alkaloids,liver function and adverse reactions were introduced.Radix Sophorae Tonkinensis was rich in quinolizidine alkaloids,mainly for te matrine,oxidation and and a small amount of anagyrine,N-methylcytisine,cytisine,oxysophocarpine,sophocarpine,Sophoramine,Sophoranol.The ef ective constituent of liver functon were matrine and oxidation,and the cause of adverse reactions was cytisine.Radix Sophorae Tonkinensis has great medicinal valve,but at the same time,the quality control is very important to reduce adverse reactions.