非甲状腺病态综合征患者血清Ghrelin的变化

Analysis of the Changes of Serum Ghrelin in Patients with Syndrome of Non Thyroidal Sick Comprehensive

目的:研究非甲状腺病态综合征(NTIS)的危重症患者血清Ghrelin水平的变化规律。方法1.测定NTIS组和正常对照组的甲状腺激素(TH)及Ghrelin的水平,并进行比较。②比较存活组和死亡组患者的TH及Ghrelin水平的变化。③比较存活组患者急性期和缓解期的TH及Ghrelin水平的变化。结果①NTIS组血清FT3、FT4、TSH及Ghrelin水平均低于对照组(P<0.05)。②死亡组血清FT3、FT4及Ghrelin明显低于存活组,有统计学差异(P<0.05)。③经治疗缓解期患者血清FT3、FT4、TSH及Ghrelin水平均明显升高,均有统计学差异(P<0.05)。结论合并NTIS危重症患者的血清Ghrelin水平的变化与甲状腺激素有一定关系,其机制目前尚不十分清楚。

Objective To investigate the changes of serum ghrelin levels in NTIS patients in critical illness.Methods 1.The serum thyroid hormone(TH),ghrelin levels were measured and compared in NTIS patients and control group.2.To compare the serum TH,ghrelin levels between survivors and death cases.3.To compare the serum TH,ghrelin levels between acute stage and convalescence in NTIS survivors.Results 1.Compared with control group,the serum FT3,FT4,TSH and ghrelin in NTIS patients were lower(P<0.05).2.The serum FT3,FT4,TSH and ghrelin levels in the death group were damatical y lower than that of the survivors(P<0.05).3.The serum FT3,FT4,TSH and ghrelin levels in convalescene were higher than that of acute stage(P<0.05).Conclusion The changes of the serum ghrelin level in NTIS patients is likely related with the serum TH.