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活性维生素D联合血管紧张素受体拮抗剂治疗慢性肾小球肾炎CKD1-2期的疗效观察

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摘要 目的:观察活性维生素阅(VD3)治疗慢性肾小球肾炎CKD1-2期的疗效及安全性。方法60例慢性肾炎CKD1-2期患者分为血管紧张素受体拮抗剂(ARB)治疗组和ARB+VD3联合治疗组,每组30例。随访12 w,所有患者均检测治疗前后血压、24澡尿蛋白定量、肾功能、血钙磷变化、C反应蛋白(CRP)、血浆肾素(PRA)等。结果治疗12 w后,ARB治疗组、联合治疗组尿蛋白、PRA较治疗前下降,有统计学意义(<0.05)。联合治疗组CRP较治疗前下降,有统计学意义(<0.05)。联合治疗组与ARB治疗组相比,联合治疗组尿蛋白、PRA减少更明显,差异有统计学意义(<0.05)。两组患者均无明显不良反应,且均未出现高钙和高磷血症。结论 VD3联合ARB治疗能有效降低慢性肾炎CKD1-2期患者尿蛋白,安全性好。其机制可能与联合用药加强抑制炎症反应及RASS系统作用有关。
作者 熊文
出处 《医学信息(医学与计算机应用)》 2014年第21期74-74,共1页 Medical Information
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