MMP-9与PTTG在胶质瘤中表达及其临床意义

Expression and Clinical Significance of MMP-9 and PTTG in Glioma

目的:对应用基质金属蛋白酶-9与垂体瘤转化酶两项指标在脑胶质瘤疾病诊断过程中所发挥的重要作用进行研究。方法将我院收治的44例患有脑胶质瘤疾病的患者和同时期同年龄段接受健康体检的健康人资料44例,分别将其定义为研究组和对照组。采用免疫组织化学方法对两组研究对象的基质金属蛋白酶-9与垂体瘤转化酶两项指标的阳性率进行测定,并对比分析测定结果。结果研究组研究对象的基质金属蛋白酶-9与垂体瘤转化酶两项指标的阳性率明显高于对照组,组间数据对比差异显著(P<0.05)。结论脑胶质瘤患者的基质金属蛋白酶-9与垂体瘤转化酶检测阳性率会明显升高,临床诊断过程中可以将这两项指标作为重要参考。

Objective To study the important role in the application of matrix metal oproteinase-9 and pituitary tumor transforming enzyme two indicators play in brain glioma diagnosis the disease process.Methods In our hospital 44 cases of patients with brain glioma disease and at the same time age accept 44 healthy people in health examination data,respectively,which is defined as the study group and the control group.Using immunohistochemical method of matrix metal oproteinases in two groups of subjects of-9 and pituitary tumor transforming enzyme two indicators of positive rate were measured,and the comparative analysis of test results.Results Matrix metalloproteinase research study group-9 and pituitary tumor transforming enzyme two indexes were significantly higher than those in the control group,the dif erence between the data comparison group significantly(P<0.05).Conclusion Matrix metal oproteinases in patients with brain glioma-9 and pituitary tumor transforming the positive rate of enzyme detection wil be significantly increased,in the process of clinical diagnosis of these two indexes can be used as an important reference.