抗真菌药物治疗外阴阴道念珠菌病敏感性的临床分析

Clinical Analysis of Antifungal Agents in the Treatment of Vulvovaginal Candidiasis Susceptibility

目的探讨抗真菌药物治疗外阴阴道念珠菌病(VVC)敏感性。方法将我院2010年~2012年收治的538例外阴阴道念珠菌病患者作为研究对象,对他们临床资料进行回顾性分析,同时对抗真菌药物治疗该病的敏感性进行观察分析。结果对538株念珠菌进行分离后可知,其中白念珠菌占了61.90%(333/538),非白念珠菌则占了38.10%(205/538)。白念珠菌及非白念珠菌,在氟康唑与伊曲康唑的敏感度上有着显著性差异(<0.05),具有统计学意义;而在酮康唑与两性霉素B的敏感度上并无显著性差异(>0.05),没有统计学意义。结论对于VVC而言,其主要的致病菌当属白念珠菌,同时白念珠菌的药物敏感性要比非白念珠菌要高,但其对抗真菌药物的耐药性却不多见。

Objective To explore the sensitivity of the antifungal treatment of vulvovaginal candidiasis.Methods To make 538 patients with the vulvovaginal candidiasis in our hospital between 2010 and 2012 as research subjects,analyze their clinical date retrospectively,and to observe and analyze the sensitivity of the antifungal to the disease.Results After the separation of candida from the 538 patients,the candida albicans accounted for 61.9%(333/538),and the non-albicans accounted for 38.1%(205/538).There were significant dif erences(<0.05)and statistical y significant between the sensitivity of Fluconazole and Itraconazole to both candida albicans and non-albicans.But there were no significant differences(>0.05)and statistical y significant between the sensitivity of Ketoconazole and Amphotericin B to both of them.Conclusion For VVC,the main pathogen was candida albicans,and the candida albicans drug sensitivity was higher than that of non-albicans,but its antifungal drug resistance was rare.