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新型口服降糖药DPP-4抑制剂研究进展 被引量:1

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摘要 糖尿病已成为危害人类健康的全球性问题。高选择性的DPP-4抑制剂成为治疗 T2DM的新靶点。DPP-4抑制剂通过抑制 DPP-4酶,提高体内 GLP-1水平,一方面改善β细胞功能;另一方面,减少α细胞不适当升高的胰高血糖素的分泌,降低血糖,抑制食欲,减慢胃排空。西格列汀、维格列汀和利格列汀是目前应用于临床的 DPP-4抑制剂,其均可有效地降低血糖,但各自作用特点不同。 DPP-4抑制剂也存在一定的安全性问题,需进一步观察研究。
作者 史存发
出处 《医学信息(医学与计算机应用)》 2014年第29期350-350,共1页 Medical Information
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