乳腺浸润性导管癌免疫分型与病理特征的关系

Analysis of the Relationship between Classification and Pathological Characteristics in Breast Infiltrating Ductal Carcinoma Immune

目的:用免疫组织化学的方法检测乳腺浸润性导管癌特定蛋白的表达并进行免疫分型,探讨不同的免疫分型与病理特征的关系。方法用 EnVision二步法检测98例乳腺浸润性导管癌ER、PR、HER-2和CK5/6,根据结果进行免疫分型。结果98例乳腺浸润性导管癌 ER、PR、HER-2和 CK5/6的阳性病例为64例、45例、24例、23例。免疫分型:管腔 A型54例、管腔 B型20例、HER-2过表达型7例、基底细胞样型9例和无法分类型8例。病理特征指标为肿块大小、组织学分级和淋巴结转移,免疫分型与组织学分级的差异具有统计学意义(P<0.05)。免疫分型与肿块大小、淋巴结转移的差异具无统计学意义(P>0.05)。结论用免疫组织化学方法对乳腺浸润性导管癌进行免疫分型,方法简便可行,对于评估预后和指导临床治疗具有一定的意义。

Objective This study try to subclassify breast cancer into dif edrnt subgroups according to immunohistochemical stain.The relationship between subtypes and pathological cariticrisetic have been disscused.Methods Nighty-eight cases of infiltrative ductal carcinoma were studied using immunohistochemical staining with the antibody panel of ER,PR,HER 2 and CK5/6.The immunological subclasify is made according to the immunohistochemical stain.and previous reports.Results The expression of ER,PR,HER-2 and CK5/6 were det ected in 65.31%,45.92%,24.49%and 23.47%.Al cases were immunoclassified into five groups,with luminal A(54 cases),luminal B(20 cases),HER-2 positive(7 cases),balal-like(9 cases)and unclassied cases(8 cases).There are statistical significant in the dif erence between immunohistochemical subtypes and histocytical groups.No statistical significant have been found between immunohistochemical subtypes and other pathological features.Conclusion Acconding to immunohistochemical stain,the infiltrative ductal carcinoma could be subclassified into five subgrtypes.There is a role in evaluating the profnosis and guiding the clinical treatment.