摘要妊娠期急性脂肪肝(AFLP,acute fatty liver of pregnancy)是一种罕见的妊娠期特发性疾病,短期内可发生多器官功能衰竭,常可危及产妇和胎儿生命。AFLP多发于妊娠晚期或产后初期阶段,常见发生于初次妊娠、多胞胎妊娠、有一男性胎儿者或有先兆子痫孕妇。AFLP患者中产妇死亡率为12.5%~18%,新生儿死亡率为7~66%[1]。我国目前尚无相关的流行病学数据。妊娠期急性脂肪肝的早期诊断和尽早终止妊娠对降低母婴死亡率至关重要。
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8Shekhawat P, Bennett MJ, Sadovsky Y, et al. Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver disease. Am J Physiol Endocrinol Metab , 2003,284 : E1098-E1105.
9Wilcken B, Leung KC, Hammond J, et al. Pregnancy and fetal long-chain 3-hydroxyacyl coenzyme A dehydrogenase deficiency. Lancet, 1993,341:407-408.
10Tyni T, Ekholm E, Pihko H. Pregnancy complications are frequent in long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. Am J Obstet Gynecol, 1998,178:603-608.
