以FreeSurfer活体测量屈光参差性弱视枕叶皮质形态学改变的MRI研究

MRI Study on Gray Matter Volume Change in Occipital Lobe in Vivo of Anisometropic Amblyopia with FreeSurfer

目的运用磁共振技术及FreeSurfer软件,对屈光参差性弱视患者枕叶皮层灰质进行分割测量。方法以1.5T磁共振对11例屈光参差性弱视患儿及11例视力正常儿童进行全脑扫描,应用三维磁化准备快速递度回波序列采集三维解剖数据,采用FreeSurfer软件进行处理分析。结果弱视患儿双侧枕叶灰质容积与对照组分别进行独立样本检验,其结果分别为P=2.618,P=0.016;P=2.515,P=0.021,有显著性差异(P<0.05)。结论 FreeSurfer对磁共振三维解剖数据的后处理可以无创性、活体测量枕叶灰质容积,屈光参差性弱视枕叶灰质容积较视力正常者降低。

Objective Using MRI(Magnetic resonance imaging)technique and the FreeSurfer software package to research the occipital lobe's gray mat er volume(GMV)change in children with Anisometropic amblyopia.Methods 11 normal sighted children and 11 children with Anisometropic amblyopia undertook MRI scans.The two groups were age-matched.Standard T1-weighted high-resolution anatomic scans with 3D-MPRAGE(three dimensional magnetization prepared rapid acquisition gradient echo)sequences were obtained for each subject.The 3-demension data were analyzed using FreeSurfer software.After inflated the brain cortex of the patients and normal groups,gray mat er volume in bilateral occipital lobe and ICV(the estimate total intracranial volume)were calculated.The statistic analyses of the data between the two groups were performed with the student t test.Results The patients of Anisometropic amblyopia showed a significant decrease in gray mat er volume compared with healthy controls:t=2.618,P=0.016;t=2.515,P=0.021(P<0.05).Conclusion Our results suggest that gray mat er volume is smal er in patients of anisometropic amblyopia compared with healthy controls;Through FreeSurfer analysis,we could observe the morphological variation of the occipital lobe without invasive.