反应活性氧与前列腺癌的研究进展

Therapeutics Potentiality of Reactive Oxygen Species for Prostate Cancer

反应活性物质是生物体内重要的组成部分,它们在机体代谢及信号传递的过程中起着重要作用。反应活性物质的种类按活性基团的不同大致可以分为以下四类院反应活性氧类(Reactive Oxygen Species,ROS),反应活性氮类(Reactive Nitrogen Species,RNS),反应活性硫类(Reactive Sulfate Species,RSS),反应活性氯类(Reactive Chloride Species,RCS)。其中以ROS含量最为丰富,相关研究也最多。ROS与RNS是机体内正常氧化呼吸代谢产物,并且在细胞信号传导途径中也发挥着重要的作用。因此,无论ROS生成增多还是清除减少都会引起体内ROS水平增高,进而导致氧化应急[1]。过量的ROS具有细胞毒性,使细胞更易罹患其他有害因素而造成损害。相关研究表明ROS通过对DNA,转录因子及细胞周期的修饰与调控,在前列腺癌的发生及发展过程中发挥着重要的作用,且抗氧化剂对预防前列腺癌具有明显效果,故本文简要对ROS其与前列腺癌之间的研究进展进行简要概述。

Reactive species,which are involved in metabolism and signaling conduction,are one of the most important parts of the organism.The reactive species family is mainly divided into four parts:Reactive Oxygen Species(ROS),Reactive Nitrogen Species(RNS),Reactive Sulfate Species(RSS)and Reactive Chloride Species(RCS).ROS is the most abundant and important species among all of them.ROS is the best studied by far,for it is the byproduct of respiratory metabolism and plays a vital role in the signaling system.The abnormal metabolism of ROS can cause oxygen stress,which leads to cellinjury even celldeath.Many studies indicate that ROS get involves in the carcinogenesis and development of prostate cancer,meanwhile the anti-oxygen drug can prevent the prostate cancer,which give rise to the intimate relationship between ROS and prostate cancer.So this review mostly are focusing on the ROS,prostate cancer and their relationship.