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单核细胞HLA-DR及血清细胞因子表达水平对重症患者免疫抑制诊断价值的研究

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摘要 目的探讨重症患者外周血单核细胞HLA-DR的表达及部分血清细胞因子水平对其免疫抑制状态的诊断价值。方法采用流式细胞术检测27例重症患者外周血单核细胞HLA-DR的表达,用CBA技术检测血清细胞因子IL-10等的水平,同时追踪患者相关感染指标。结果27例重症患者中HLA-DR表达率约40%者5例,IL-10(7.603依4.123)pg/mL,HLA-DR表达率40%~85%者10例,IL-10(7.368依9.995)pg/mL,HLA-DR表达率跃85%者12例,IL-10(2.248依1.556)pg/mL。结论重症患者外周血单核细胞HLA-DR表达率低于正常对照,监测HLA-DR的表达及相关细胞因子水平对判断患者的免疫功能状态有较好的临床意义。
作者 张福秀
出处 《医学信息(医学与计算机应用)》 2014年第12期308-309,共2页 Medical Information
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