宫颈细胞DNA检测筛查宫颈病变1510例体会

Cervical Cell DNA Detection in the Screening of Cervical Lesions in 1510 Cases

目的探讨DNA定量分析检查在宫颈病变筛查中的应用价值。方法对2013年1月~12月我科门诊1510例患者宫颈脱落细胞进行DNA定量分析,以活检的病理组织学诊断为金标准,分析该种方法对诊断宫颈病变的临床意义。结果DNA异倍体细胞的检出率为33.84%;其中异常倍体细胞出现3个以上患者189例占12.51%,以3个以上DNA异倍体出现作为活检标准,并经患者知情同意行宫颈活检109例,宫颈病变的检查阳性70例,检出率为64.22%。结论细胞DNA定量分析检测敏感性高,适用于宫颈早期病变的筛查。

Objective To investigate the inspection application value in screening of cervical lesions of DNA quantitative analysis.Methods From 2013 to January^12 months in our department 1510 patients of cervical exfoliated cellDNA quantitative analysis to biopsy,pathological diagnosis as the gold standard,the clinical significance of this method for the diagnosis of cervical lesions.Results The detection of DNA aneuploid cellrate is 33.84%;the aneuploidy cells appeared more than 3 patients 189 cases accounted for 12.51%,with more than 3 DNA aneuploidy as biopsy criteria,and the informed consent of patients underwent cervical biopsy in 109 cases,cervical lesions,70 cases were positive,the detection rate of 64.22%.Conclusion Cell DNA quantitative analysis and detection sensitivity,screening for early cervical lesions.