纳米碳在甲状腺乳头状癌前哨淋巴结活检中的应用

Application of Carbon Nanoparticle Suspension Injection in the Sentinel Lymph Node (SLN) Biopsy for Papillary Thyroid Carcinoma

目的探讨纳米碳混悬液对甲状腺乳头状癌前哨淋巴结示踪的效果。方法对76例甲状腺乳头状癌患者,术中于甲状腺病灶周围分4点注射纳米碳混悬液,每点约0.1~0.2ml,10min内甲状腺腺叶及颈部淋巴结相继黑染,首先黑染的中央区淋巴结即为前哨淋巴结,然后行中央区淋巴结清扫术。结果本组成功检查前哨淋巴结72例,检出率为94.7%,灵敏度为89.2%(33/37),准确率为94.4%(68/72),假阴性率10.8%(4/39)。结论纳米碳混悬液作为示踪剂能准确反映甲状腺癌颈部淋巴结转移状态,为临床缩小甲状腺乳头状癌手术范围和减少术后并发症提供重要参考。

Objective To explore the tracing effect of the carbon nanoparticle suspension injection in the sentinel lymph node(SLN)biopsy of Papil ary thyroid carcinoma.Methods 76 patients with Papil ary thyroid carcinoma underwent lymphatic tracing with the carbon nanoparticle suspension injection.The carbon nanoparticle suspension was injected into the thyroid gland during operation.The lymphnodes blacked were named SLN.Results The detection rate of SLN was 94.7%.The correct,sensitive and false negative rates were 94.4%,89.2%and 10.8%respectively.Conclusion The carbon nanoparticle suspension injection in SLN biopsy is helpful for accurately evaluating the neck lymphnode condition,and decreases the extension of surgery and postoperative complications in patients with Papillary thyroid carcinoma.