2Schott JJ, Benson DW, Besson CT, et al. Congenital heart disease caused by mutations in the transcription factor NKX 2.5. Science, 1998,281 : 108-111.
3Poseh MG, Pcrret A, Schmitt K, et al. Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects. Am J Med Genet A,2008,46A :251-253.
4Pashmforoush M, Lu JT, Chert H,et al. Nkx2.5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell, 2004,117:373-386.
5Elliott DA, Kirk EP, Thomas Y. Cardiac homeobox gene NKx 2. 5 mutations and congenital heart disease. J Am Coll Cardiol, 2003,41: 2072-2076.
6McElhinney DB,Geiger E,Blinder J,et al. Nkx 2.5 mutations in patients with congenital heart disease. J Am Coll Cardiol, 2003,42: 1650-1655.
7Inga A, Reamon-Buettner SM, Borlak J, et al. Functional dissection of sequence specific NKx 2.5 DNA binding domain mutations associated with human heart septation defects using a yeast based system. Hum Mol Genet,2005,14 (14) : 1965-1975.
8Jay PY, Harris BS, Maguire CT, et al. Nkx-2, 5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest, 2004,113:1130-1137.
9Yu Chen, Zengqiang Han, Chuzhong Tang, et al. A novel mutation in GATA-4 gene associated with dominant inherited familial atrial septal defect. J Thorac Cardiovascr Surg,2010,140(3) : 684-687.
10Evans WE, McLeod HL. Pharmacogenomies-drug disposition, drug targets,and side effects. N Engl J Med,2003,348(6) :538-549.