恶性肿瘤再程放疗的疗效观察

Effectiveness of Re-irradiation for Patients with Malignant Tumor

目的观察恶性肿瘤再程放疗的疗效。方法回顾性分析29例接受再程放疗的患者,其中食管癌15例,鼻咽癌5例,椎体转移癌3例,宫颈癌、直肠癌、鼻腔NK/T细胞淋巴瘤、脑转移癌、髓母细胞瘤和脑胶质瘤各1例,肿瘤靶区剂量30~50Gy/10~25f。结果对存在可评价病灶者,在放疗结束后取得完全缓解(CR)者为38.5%(10例/26例),部分缓解(PR)为46.2%(12例/26例),1例(3.8%)稳定(SD),2例(7.7%)PD,1人未评估。无进展生存期为4~36个月,中位时间8个月,1年的无进展生存率(PFS)为65%。严重的急性和晚期放射反应发生率分别为6.9%。结论再程放疗安全、有效。

To observe the effectiveness of re-irradiation for malignant tumor.Methods 29 paitents with malignant tumor re-irradiated were enrol ed,in whom 15 patients with esophageal cancer,5 with nasopharyngeal cancer,3 with spinal bone metastases,one with rectal cancer,one with cervical cancer,one with NK/T lymphoma in nasal cavity,one with metastatic brain tumor,one with medul oblastoma and one with cerebral glioma.The total dose of GTV was 30~50Gy with 2~3Gy per fraction.Results For the 26 evaluable patients,complete response was 38.5%,partial response was 46.2%,stable disease was 3.8%and progress disease was 7.7%.One patient did not receive the evaluation.The median time to progression was 8 months(range:4~36 months),and the 1-year progression free survival was 65%.The severe acute and late adverse events occurred in 6.9%of patients,respectively.Conclusion Re-irradiation was ef ective and showed acceptable toxicity.