复发性自然流产与免疫因素和遗传性凝血缺陷关系的研究

Study of Recurrent Spontaneous Abortion and Immune Factors and Hereditary Coagulation Defect Relations

目的:关于复发性自然流产与免疫因素及遗传性凝血缺陷之间关联性的研究。方法通过对60例有复发性自然流产史的女性进行相关免疫因素中抗体检测及PAI-1基因启动子4G/5G基因多态性检测,正常妊娠人群做为对照组,结果进行统计学分析。结果复发性自然流产组的抗心磷脂抗体(ACA)阳性率及抗β-糖蛋白-1抗体(β2GP1-IgG/IgM)阳性率均明显高于正常对照组(P<0.01,具有统计学意义)。复发自然流产组的PAI-14G/4G基因型分布明显高于对照组。结论复发性自然流产病因与免疫因素及遗传性凝血缺陷有很大关联,对临床诊治有重要指导意义。

Objective About recurrent spontaneous abortion and immune factors and genetic study of correlation between blood coagulation defects.Methods Through the 60 cases with a history of recurrent spontaneous abortion women related immune factors in antibody detection and PAI-1 gene promoter 4 g/5 g gene polymorphism,normal pregnancy group as control group,the results were statistical y analyzed.Results The recurrent spontaneous abortion group,anti cardiolipin antibody(ACA)antibody positive rate and resistance to beta glycoprotein-1(beta 2 gp1-IgG/IgM)positive rate were significantly higher than that of normal control group(P<0.01,statistical y significant).Recurrent spontaneous abortion group of PAI-1 4 g/4 g genotype distribution was obviously higher than the control group.Conclusion recurrent spontaneous abortion etiology and immune factors and hereditary coagulation defects are highly correlated,has important guiding significance to the clinical diagnosis and treatment.