经济型HAG/CAG方案治疗老年急性髓细胞白血病及高危骨髓增生异常综合征疗效比较

Abnormal Syndrome of Comparative Economic Type HAG/CAG in the Treatment of Dlderly Patients with Acute Myeloid Leukemia and High Risk Myelodysplastic

目的:探讨老年急性髓细胞白血病及高危骨髓增生异常综合征采用 HAG/CAG方案治疗效果对比情况。方法本次共选择40例老年高危骨髓增生异常综合征和急性髓细胞白血病患者作研究对象,均为我院2013年1月~2014年1月收治,随机分组,分别采用经济型 HAG(n=20)或 CHG(n=20)治疗,回顾并对比临床资料。结果研究组临床治疗总有效率(80.00%)虽略高于对照组(70.00%),但两组患者临床疗效对比结果无统计学意义(P>0.05)。研究组患者不良反应发生率为45.00%,显著低于对照组70.00%,对比结果具有统计学意义(P<0.05)。两组患者不良反应均为I级或II级,无严重不良反应发生,经对症干预后均好转或痊愈,可坚持完成治疗。结论老年AML及MDS采用经济型HAG/CAG方案治疗,CAG效果更为显著,且不良反应发生率较低,安全性较高,值得临床推广应用。

Objective To investigate the elderly patients with acute myeloid leukemia and high risk myelodysplastic syndrome by contrast the curative ef ect of HAG/CAG scheme.Methods The total 40 cases of elderly high-risk myelodysplastic syndrome and acute myeloid leukemia patients as the research object,are in our hospital from 2013 January to 2014 January were randomly,respectively,economic type HAG(n=20)or CHG(n=20)treatment,review and comparison of clinical data.Results The study group clinical total ef ective rate(80%)is slightly higher than that of the control group(70%),but the two groups of patients with clinical curative ef ect contrast the results were not statistical y significant(P>0.05).Research groups in the incidence of adverse reaction was 45%,significantly lower than the control group 70%,contrast the results with statistical significance(P<0.05).Two groups of patients with adverse reactions are I or II,no serious adverse reactions,the interventions were improved or cured,can adhere to the completion of treatment.Conclusion Elderly AML and MDS using HAG/CAG regimen in the treatment of CAG,the ef ect is more remarkable,and low incidence rate of adverse reaction,high security.For the first time chemotherapy is inef ective,2 schemes are applied alternately,with higher safety and ef icacy,is worthy of clinical application.