不同剂量奥美拉唑治疗溃疡性上消化道出血的疗效比较

Different Doses of Omeprazole in the Treatment of Ulcer of Upper Gastrointestinal Hemorrhage

目的比较大剂量奥美拉唑和常规剂量奥美拉唑治疗溃疡性上消化道出血的治疗效果。方法选取156例患者随机分为治疗组和对照组各78例。治疗组院先给予奥美拉唑80mg加入生理盐水20ml缓慢静脉推注,约5~10min推完,然后再将奥美拉唑80mg加入生理盐水共50ml加入微量泵,以8mg/h的速度持续泵入,持续泵入72h;对照组院予奥美拉唑40mg加入生理盐水100ml,以q12h频率静脉滴注,用药72h。观察比较两组患者止血有效率、再出血情况、输红细胞悬液量、不良反应等。结果总有效率(<0.05)院治疗组94.8%,对照组总有效率为80.7%。72h再出血率(<0.05)院治疗组1.28%,对照组6.41%;平均每例输红细胞悬液输入量(<0.05)院治疗组(2.0±1.0)U,对照组(4.0±1.1)U;两组患者均无明显不良反应。结论大剂量奥美拉唑组对急性溃疡性上消化道出血止血效果明显优于常规剂量奥美拉唑组,无明显不良反应,且能缩短住院时间、节约患者住院费用,值得基层医院进一步推广应用。

Objective To compare high-dose omeprazole and routine dose of omeprazole in the treatment of ulcerative upper digestive tract hemorrhage treatment ef ect.Methods 156 patients were randomly divided into treatment group and control group with 78 cases in each.Treatment group:first given omeprazole 80mg join saline 20ml slow intravenous injection,about 5~10 minutes to finish,and then omeprazole 80mg join saline 50ml adding trace pump continuous infusion,with the speed of 8mg/h,continuous infusion of 72 hours;the control group:Omeprazole 40mg join saline 100ml,at a frequency of q12h intravenous drug use,72 hours.The two groups were observed and compared hemostatic efficiency,rebleeding rate,transmission and suspension of red blood cells,adverse reaction.Results The total ef ective rate(<0.05):treatment group 94.8%,control group total ef ectiveness is 80.7%;.72 re bleeding rate in H(<0.05):treatment group 1.28%,control group 6.41%;the average cases of red blood celltransfusion suspension input(<0.05):the treatment group(2±1)U,the control group(4±1.1)U;two groups were no obvious adverse reactions.Conclusion Large dose of omeprazole group on the hemostatic effect is bet er than conventional dose of omeprazole group of acute upper digestive tract bleeding ulcer,no significant adverse reactions,and can shorten the time of hospitalization,hospitalization cost saving,worthy of further application in basic hospital.