大肠埃希氏菌对喹诺酮类药物的耐药现状及防治

Prevalence and Resistance Status of Escherichia Coli in Quinolones and Its Prevention and Cure Strategies

喹诺酮类药物(Quinolones,Qs)是一类合成广谱抗菌药,自20世纪60年代萘啶酸被运用于临床医学以后,同时喹诺酮类药物的耐药问题便接踵而至,这使得喹诺酮类药物成为开发最活跃,更新换代最迅速的药物。由于其具有抗菌谱广,抗菌活性强,与常用抗菌药物无交叉耐药,已成为临床治疗感染性疾病的主要药物之一。然而,随着喹诺酮类药物在人医和兽医临床的广泛、长期、大量盲目滥用,使得其耐药性近年呈蔓延增长趋势,耐药程度越来越重,耐药菌株越来越多。其中,大场杆菌对喹诺酮类药物的耐药性问题是当前国内外研究的热点。本文综述了大肠杆菌对氟喹诺酮类药物耐药现状及特点,并分析了其耐药机制,简要综述了减缓耐药性的一些防治策略。

The Quinolones is a kind of synthetic wide table antimicrobial,Dixiben was applied to clinic medicine since the sixties of the 20th century the question of resistance of Quinolones appeared at the same time that made Quinolones become and develop the most active,update the fastest medicine.Because it has antibacterial wide tables,the antibacterial activity is strong and have not been cross resistance with daily antibacterial medicines,have become one of the clinical main medicines to treat the infective disease.However,as the Quinolones abuse in people and veterinarian's medicine and clinical y extensively and long-termly and in a large amount led to bacterias resistance to quinolones show a tendency to spread and increase in recent years,resistance degree to be more and more heavy,resistance of strains are more and more many.Quinolone resistance in Escherichia coli is a focus studied both at home and abroad at present.The review focuses on prevalence and resistance status of E.coli in Quinolones,the mechanism of Quinolones resistance in E.coli and provides some prevention and cure strategies slow-down dug-resistance.