翼状胬肉切除术后角膜融解与非甾体类消炎药关系

The Relationship between the Corneal Melting and Nonsteroidal Anti-inflammatory Drug after Excision of Pterygium

目的:探讨非甾体类消炎药(NSAIDs)与角膜融解间的联系。方法对98眼翼状胬肉的患者行翼状胬肉切除手术,随机分为来那个组。观察组:50眼术后使用非甾体类消炎药(双氯芬酸钠眼液)、典必舒、贝复舒点眼。对照组:48眼术后使用典必舒、贝复舒点眼。结果两组间比较,术后3d观察组发生角膜溶解2例,对照组无发生;术后1w内观察组发生角膜溶解12例,对照组发生角膜溶解4例,二者比较差异有统计学意义(P<0.05);术后2w观察组再发生角膜溶解1例,对照组无发生。结论非甾体类消炎药可引起角膜融解,并针对病因学进行讨论,并且针对个体情况推荐合理的非甾体消炎药使用方法。

Objective:To study the relationship between the use of nonsteroidal anti-inflammatory drug(NSAIDs)and the corneal melting.Methods:98 eyes of pterygium underwent pterygium excision operation,were randomly divided into 2 groups.The observation group:In 50 eyes after the operation use non steroidal anti-inflammatory drugs(diclofenac sodium eye drops),TobraDex,bFGF.control group:In 48 eyes after the operation use TobraDex,and bFGF.Results:After three days of the operation,observation group had corneal dissolution in 2 cases,control group without any;After a week of the operation,observation group had corneal dissolution in 12 cases,control group had corneal dissolution in 4 cases,There was statistical y significant dif erence between the two groups(P<0.05);After two weeks of the operation,observation group had corneal dissolution in 1 cases,control group without any.Conclusion:Non steroidal anti-inflammatory drugs can cause corneal melting.