摘要
目的:分析探讨辛伐他汀对高血压合并颈动脉斑块患者血管内皮功能及颈动脉斑块的影响及疗效。方法所有入选患者维持原有降压方案不变,研究组予以辛伐他汀(舒降之,默沙东公司)20mg,每晚一次口服,持续治疗12w。研究组治疗前及治疗后12w后分别行彩色多普勒超声和血清学指标检查。结果研究组IMT、hsCRP值高于对照组,差异有显著性(P<0.05);FMD值低于对照组,差异具有显著性(P<0.05),而 TG、TC、LDL-C、HDL-C、FBG及 NMD值无显著性差异(P>0.05)。辛伐他汀治疗后颈动脉IMT和斑块积分较治疗前明显减小,血管内皮依赖性舒张功能(FMD)改善,hsCRP及TG、TC、LDL-C降低,差异具有统计学意义(P<0.05);而NMD值无显著性差异(P>0.05)。结论辛伐他汀可以有效改善高血压合并动脉粥样硬化患者血管内皮功能,临床疗效值得肯定。
Objective Analysis on the ef ect of simvastatin on carotid plaques in patients with hypertension and vascular endothelial function and carotid artery plaque and curative ef ect.Methods Al patients maintained the original antihypertensive therapy remains unchanged,the study group treated with simvastatin(Shu Jiangzhi,Merck)20mg,QN,treatment was continued for 12 weeks.Study group before treatment and 12 weeks after treatment were performed color Doppler ultrasonography and serology examination.Results HsCRP IMT,the study group was higher than the control group,there was significant dif erence(P<0.05);the FMD value is lower than the control group,the dif erence was significant(P<0.05),while TG,TC,LDL-C,HDL-C,FBG and NMD values had no significant dif erence(P>0.05).Simvastatin treatment of carotid IMT and plaque score was significantly lower than that before treatment reduced,vascular endothelial dependent diastolic function(FMD),hsCRP and TG,TC,LDL-C decreased,the dif erence was statistical y significant(P<0.05);while the NMD value had no significant dif erence(P>0.05).Conclusions Simvastatin can ef ectively improve endothelial function in atherosclerosis in patients with hypertension,the clinical ef ect is positive.
作者
谭建军
TAN Jian-jun(Sichuan Province Deyang City Zhongjiang County People's Hospital,Deyang,Sichuan 618100,China)
